Laser-Induced Ocular Hypertension in Albino CD-1 Mice
نویسندگان
چکیده
منابع مشابه
Laser-induced ocular hypertension in albino CD-1 mice.
PURPOSE To establish a laser-induced model of ocular hypertension (LIOH) in albino CD-1 mice and to characterize the sequence of pathologic events triggered by intraocular pressure (IOP) elevation. METHODS LIOH was induced unilaterally in CD-1 mice by laser photocoagulation of limbal and episcleral veins 270 degrees to 300 degrees circumferentially, sparing the nasal aspect and the long cilia...
متن کاملFunctional and morphological effects of laser-induced ocular hypertension in retinas of adult albino Swiss mice
PURPOSE To investigate the effects of laser photocoagulation (LP)-induced ocular hypertension (OHT) on the survival and retrograde axonal transport of retinal ganglion cells (RGC), as well as on the function of retinal layers. METHODS Adult albino Swiss mice (35-45 g) received laser photocoagulation of limbal and episcleral veins in the left eye. Mice were sacrificed at 8, 17, 35, and 63 days...
متن کاملComparison of laser and circumlimbal suture induced elevation of intraocular pressure in albino CD-1 mice
Animal models of ocular hypertension are important tools for glaucoma studies. Both acute transient models and chronic models of ocular hypertension may be useful to investigate specific aspects of neurodegeneration. In this study, we compare the intraocular pressure (IOP) and inner retinal changes induced by 1) laser photocoagulation of both episcleral veins and limbal vessels and 2) circumlim...
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PURPOSE To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. METHODS Osmotic mini-pumps were implanted subcutaneously into C57BL/6J mice for systemic delivery of...
متن کاملLaser-induced mouse model of chronic ocular hypertension.
PURPOSE To develop an inducible mouse model of glaucoma. METHODS An obstruction of aqueous humor outflow in adult C57BL6/J mice was induced by combined injection of indocyanine green (ICG) dye into the anterior chamber and diode laser treatment. To evaluate intraocular pressure (IOP), tonometry was performed with a modified Goldmann tonometer. The function of the retina was evaluated with ele...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2010
ISSN: 1552-5783
DOI: 10.1167/iovs.09-4324